実績

公的補助金等

経済産業省 平成27年度補正ものづくり・商業・サービス新展開支援補助金

経済産業省 中小企業等経営強化法に関わる経営力向上計画の認定

原著

Minodronic Acid in Combination with γδT Cells Induces Apoptosis of Non-small Cell Lung Carcinoma Cell Lines.
Yasukawa M, Nakazawa T, Kawaguchi T, Kawai N, Tsujimura T, Tojo T, Taniguchi S.
Anticancer Res. 36:5883-5886. 2016

Antitumor effects of minodronate, a third-generation nitrogen-containing bisphosphonate, in synergy with γδT cells in human glioblastoma in vitro and in vivo.
Nakazawa T, Nakamura M, Matsuda R, Nishimura F, Park YS, Motoyama Y, Hironaka Y, Nakagawa I, Yokota H, Yamada S, Tamura K, Takeshima Y, Omoto K, Tanaka Y, Ouji Y, Yoshikawa M, Tsujimura T, Nakase H.
J Neurooncol. 129:231-241. 2016

Cytotoxic human peripheral blood-derived γδT cells kill glioblastoma cell lines: implications for cell-based immunotherapy for patients with glioblastoma.
Nakazawa T, Nakamura M, Park YS, Motoyama Y, Hironaka Y, Nishimura F, Nakagawa I, Yamada S, Matsuda R, Tamura K, Sugimoto T, Takeshima Y, Marutani A, Tsujimura T, Ouji N, Ouji Y, Yoshikawa M, Nakase H.
J Neurooncol. 116:31-39. 2014

Characterization and expansion of human peripheral blood γδ T cells.
Tsujimura T, Nakazawa T, Matsuo Y, Imanishi J.
J Kyoto Pref Univ of Med. 118:711-722. 2009

Correlations of sleep disturbance with the immune system in type 2 diabetes mellitus.
Tsujimura T, Matsuo Y, Keyaki T, Sakurada K, Imanishi J.
Diabetes Res Clin Pract. 85:286-292. 2009

Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines.
Furukawa Y, Vu HA, Akutsu M, Odgerel T, Izumi T, Tsunoda S, Matsuo Y, Kirito K, Sato Y, Mano H, Kano Y.
Leukemia. 21:1005-1014.2007

Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells.
Miura Y, Nishimura Y, Katsuyama H, Maeda M, Hayashi H, Dong M, Hyodoh F, Tomita M, Matsuo Y, Uesaka A, Kuribayashi K, Nakano T, Kishimoto T, Otsuki T.
Apoptosis. 11:1825-1835. 2006

Inhibitory effects of anti-oxidants on apoptosis of a human polyclonal T-cell line, MT-2, induced by an asbestos, chrysotile-A.
Hyodoh F, Takata-Tomokuni A, Miura Y, Sakaguchi H, Hatayama T, Hatada S, Katsuyama H, Matsuo Y, Otsuki T.
Scand J Immunol. 61:442-448. 2005

発表

国際学会

Minodronate exerts antitumor effects against human glioblastoma in cooperation with peripheral blood-derived γδ T cells.
Nakazawa T, Nakamura M, Matsuda R, Park YS, Motoyama Y, Hironaka Y, Nishimura F, Nakagawa I, Tamura K, Takeshima Y, Marutani A, Omoto K, Tanaka Y, Ouji Y, Yoshikawa M, Tsujimura T, Nakase H.
International Conference of Cancer Immunotherapy and Macrophages, 2015, Tokyo

Cytotoxic human peripheral blood-derived γδT cells kill glioblastoma cell lines.
Nakazawa T, Tsujimura T.
The 73rd Annual Meeting of the Japanese Cancer Association, 2014, Yokohama

The effectiveness of valproic acid for malignant glioma in the temozolomide era.
Matsuda R, Nakamura M, Nakazawa T, Tamura K, Yamada S, Nishimura F, Nakagawa I, Motoyama Y, Park YS, Nakase H.
The 10th Meeting of the Asian Society for Neuro-Oncology, 2013, Mumbai

Expansion of human natural killer cells in vitro.
Nakazawa T, Tsujimura T, Imanishi J, Matsuo Y.
The 68th Annual Meeting of the Japanese Cancer Association, 2009, Yokohama

Characterization of expanded γδ T cells derived from human peripheral blood.
Nakazawa T, Tsujimura T, Imanishi J, Matsuo Y.
The 67th Annual Meeting of the Japanese Cancer Association, 2008, Nagoya

Determination of heterogeneity of in vitro expanded peripheral blood γδT cells derived from human peripheral blood.
Shiomi R, Nakazawa T, Tsujimura T, Imanishi J, Matsuo Y.
The 38th Annual Meeting of the Japanese Society for Immunology, 2008, Kyoto

Establishment of regulatory γδT cell line derived from human T cell leukemia virus type I career.
Nakazawa T, Tsujimura T, Imanishi J, Matsuo Y.
The 66th Annual Meeting of the Japanese Cancer Association, 2007, Yokohama

Establishment and characterization of regulatory T cell-like γδT cell line derived from human peripheral blood.
Nakazawa T, Tsujimura T, Imanishi J, Matsuo Y.
The 37th Annual Meeting of the Japanese Society for Immunology, 2007, Tokyo

Expansion of NKT cells and specific cytotoxicity against cell lines derived from multiple myelomas.
Nakazawa T, Tsujimura T, Imanishi J, Matsuo Y.
The 65th Annual Meeting of the Japanese Cancer Association, 2006, Yokohama

国内学会

高純度NK細胞を用いた膠芽腫細胞に対する抗腫瘍効果とTMZを用いた併用効果の基礎的検討
田中祥貴、中澤務、中村光利、辻村貴弘、尾本幸治、竹島靖浩、松田良介、田村健太郎、山田修一、中川一郎、西村文彦、横田浩、本山靖、朴永銖、中瀬裕之
第14回日本免疫治療学研究会学術集会、2017年、東京

ミノドロン酸の抗非小細胞肺癌効果の検討
安川元章、東条尚、川口剛史、河合紀和、中澤務、辻村貴弘
第56回日本肺癌学会学術集会、2015年、横浜

膠芽腫細胞株におけるミノドロン酸の抗腫瘍効果の検討
松田良介、中村光利、中澤務、西村文彦、辻村貴弘、中瀬裕之
第12回日本免疫治療学研究会学術集会、2015年、東京

ヒト末梢血由来細胞傷害性γδT細胞は膠芽腫細胞株を殺傷する
中澤務、中村光利、松田良介、朴永銖、本山靖、新靖史、弘中康雄、中川一郎、西村文彦、丸谷明子、王寺典子、辻村貴弘、王寺幸輝、吉川正英、中瀬裕之
第18回日本がん免疫学会総会、2014年、愛媛

ヒト神経膠芽腫細胞株に対するヒト末梢血由来γδT細胞の細胞傷害活性について
中澤務、中村光利、朴永銖、本山靖、弘中康雄、西村文彦、中川一郎、山田修一、松田良介、杉本正、竹島靖浩、丸谷明子、王寺幸輝、吉川正英、辻村貴弘、中瀬裕之
第13回日本分子脳神経外科学会学術集会、2012年、熊本